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How to Use

Melatonin Use Safety:

Melatonin occurs naturally in the body and is markedly safe for many levels of use.

In long-term research studies, continued use of melatonin supplementation up to 500 mg have not produced any reportable adverse side effects. Recommended use of Ascent Instant Nasal Spray delivers 0.6 mg of melatonin, yielding a therapeutic index (ratio of toxic dose to therapeutic dose) of at least 833. For comparison, acetaminophen (Tylenol/Advil) is much more toxic with a therapeutic index of only 2.5. 

Relevant Research:

  • Emet M, Ozcan H, Ozel L, Yayla M, Halici Z, Hacimuftuoglu A. A Review of Melatonin, Its Receptors and Drugs. Eurasian J Med. 2016;48(2):135-141. doi:10.5152/eurasianjmed.2015.0267
  • van den Berg, M.P., Merkus, P., Romeijn, S.G. et al. Uptake of Melatonin into the Cerebrospinal Fluid After Nasal and Intravenous Delivery: Studies in Rats and Comparison with a Human Study. Pharm Res 21, 799–802 (2004).
  • Tan, D. X., Xu, B., Zhou, X., & Reiter, R. J. (2018). Pineal calcification, melatonin production, aging, associated health consequences and rejuvenation of the pineal gland. Molecules23(2), 301.
  • Patent: US6007834A


Not intended to treat, diagnose, or cure any disease or ailment. Please read and fully understand potential adverse effects before using this product. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent diseases.

Please consult your doctor before using any supplements, especially if you have any medical conditions.